PACE - The first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial

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PACE - The first placebo controlled trial of paracetamol for acute low back pain: design of a randomised controlled trial

BACKGROUND Clinical practice guidelines recommend that the initial treatment of acute low back pain (LBP) should consist of advice to stay active and regular simple analgesics such as paracetamol 4 g daily. Despite this recommendation in all international LBP guidelines there are no placebo controlled trials assessing the efficacy of paracetamol for LBP at any dose or dose regimen. This study a...

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PACE – the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan

BACKGROUND Paracetamol (acetaminophen) is recommended in most clinical practice guidelines as the first choice of treatment for low back pain, however there is limited evidence to support this recommendation. The PACE trial is the first placebo controlled trial of paracetamol for acute low back pain. This article describes the statistical analysis plan. RESULTS PACE is a randomized double dum...

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Acupuncture for acute non-specific low back pain: a randomised, controlled, double-blind, placebo trial.

OBJECTIVE To assess the efficacy of Yamamoto's acupuncture method on pain, drug intake, functional capacity and quality of life for the treatment of acute non-specific low back pain (ANLBP). METHODS A prospective, randomised, parallel-group, double-blind, placebo-controlled trial was performed in 80 men and women with ANLBP who were randomly assigned to five acupuncture sessions (intervention...

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Relief of low back pain immediately after acupuncture treatment--a randomised, placebo controlled trial.

BACKGROUND The purpose of this study was to examine the immediate effect of single acupuncture stimulation to the most painful point in patients with low back pain. METHOD A randomised, evaluator-blinded, sham controlled clinical trial was conducted in which 31 patients with low back pain were randomly allocated to either an acupuncture group (n = 15) or a sham acupuncture group (n = 16). Bot...

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Implementation of RCGP guidelines for acute low back pain: a cluster randomised controlled trial.

BACKGROUND The Royal College of General Practitioners (RCGP) has produced guidelines for the management of acute low back pain in primary care. AIM To investigate the impact on patient management of an educational strategy to promote these guidelines among general practitioners (GPs). DESIGN OF STUDY Group randomised controlled trial, using the health centre as the unit of randomisation. ...

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ژورنال

عنوان ژورنال: BMC Musculoskeletal Disorders

سال: 2010

ISSN: 1471-2474

DOI: 10.1186/1471-2474-11-169